Ontology highlight
ABSTRACT:
SUBMITTER: Hansotia T
PROVIDER: S-EPMC1705821 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Hansotia Tanya T Maida Adriano A Flock Grace G Yamada Yuichiro Y Tsukiyama Katsushi K Seino Yutaka Y Drucker Daniel J DJ
The Journal of clinical investigation 20061221 1
The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) control glucose homeostasis through well-defined actions on the islet beta cell via stimulation of insulin secretion and preservation and expansion of beta cell mass. We examined the importance of endogenous incretin receptors for control of glucose homeostasis through analysis of Glp1r(-/-), Gipr(-/-), and double incretin receptor knockout (DIRKO) mice fed a high-fat (HF) diet. DIRKO mic ...[more]