Compensatory relationship between splice sites and exonic splicing signals depending on the length of vertebrate introns.

ABSTRACT:

Background

The signals that determine the specificity and efficiency of splicing are multiple and complex, and are not fully understood. Among other factors, the relative contributions of different mechanisms appear to depend on intron size inasmuch as long introns might hinder the activity of the spliceosome through interference with the proper positioning of the intron-exon junctions. Indeed, it has been shown that the information content of splice sites positively correlates with intron length in the nematode, Drosophila, and fungi. We explored the connections between the length of vertebrate introns, the strength of splice sites, exonic splicing signals, and evolution of flanking exons.

Results

A compensatory relationship is shown to exist between different types of sign

SUBMITTER: Dewey CN 

PROVIDER: S-EPMC1713244 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature