Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model.

ABSTRACT:

Background

microRNAs (miRNAs) are a group of non-coding single stranded RNAs measuring approximately 22 nt in length that have been found to control cell growth, differentiation and apoptosis. miRNAs negatively regulate their target genes and recently have been implicated in tumourigenesis. Furthermore, miRNA expression profiling correlates with various cancers, with these genes thought to act as both tumour suppressors and oncogenes. ret/PTC 1 is an oncogene with constitutive kinase activity implicated in the development of papillary thyroid carcinoma (PTC). This rearrangement leads to aberrant MAPK activation that is implicated in PTC tumourigenesis.

Aim

The aim of this study was to identify the effect that ret/PTC 1 has on transcription and post-transcriptional regulation

SUBMITTER: Cahill S 

PROVIDER: S-EPMC1713250 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature