Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial.

ABSTRACT:

Objectives

Previous studies of a fixed combination including cotrimoxazole, rifampicin, and isoniazid (Cotrifazid) showed efficacy against resistant strains of Plasmodium falciparum in animal models and in small-scale human studies. We conducted a multicentric noninferiority trial to assess the safety and efficacy of Cotrifazid against drug-resistant malaria in Papua New Guinea.

Design

The trial design was open-label, block-randomised, comparative, and multicentric.

Setting

The trial was conducted in four primary care health facilities, two in urban and two in rural areas of Madang and East Sepik Province, Papua New Guinea.

Participants

Patients of all ages with recurrent uncomplicated malaria were included.

Interventions

Patients were randomly assigned

SUBMITTER: Genton B 

PROVIDER: S-EPMC1713262 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature