A gene expression signature predicts survival of patients with stage I non-small cell lung cancer.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related death in the United States. Nearly 50% of patients with stages I and II non-small cell lung cancer (NSCLC) will die from recurrent disease despite surgical resection. No reliable clinical or molecular predictors are currently available for identifying those at high risk for developing recurrent disease. As a consequence, it is not possible to select those high-risk patients for more aggressive therapies and assign less aggressive treatments to patients at low risk for recurrence.

Methods and findings

In this study, we applied a meta-analysis of datasets from seven different microarray studies on NSCLC for differentially expressed genes related to survival time (under 2 y and over 5 y). A consensus set of 4,905 gen

SUBMITTER: Lu Y 

PROVIDER: S-EPMC1716187 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature