A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies.

ABSTRACT:

Background

Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The "rules" governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially established, or what determines tumor type-specific methylation are unknown. However, DNA methylation markers that are highly specific and sensitive for common tumors would be useful for the early detection of cancer, and those required for the malignant phenotype would identify pathways important as therapeutic targets.

Methods and findings

In an effort to identify new cancer-specific methylation markers, we employed a high-throughput global expression profiling approach in lung cancer cell

SUBMITTER: Shames DS 

PROVIDER: S-EPMC1716188 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature