Lipoprotein particle profiles mark familial and sporadic human longevity.

ABSTRACT:

Background

Genetic and biochemical studies have indicated an important role for lipid metabolism in human longevity. Ashkenazi Jewish centenarians and their offspring have large low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles as compared with control individuals. This profile also coincided with a lower prevalence of disease. Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population.

Methods and findings

NMR-measured lipoprotein profiles were analyzed in 165 families from the Leiden Longevity Study, consisting of 340 long-lived siblings (females >91 y, males >89 y), 511 of their offspring, and 243 partners of

SUBMITTER: Heijmans BT 

PROVIDER: S-EPMC1716190 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature