PANTHER version 6: protein sequence and function evolution data with expanded representation of biological pathways.

ABSTRACT: PANTHER is a freely available, comprehensive software system for relating protein sequence evolution to the evolution of specific protein functions and biological roles. Since 2005, there have been three main improvements to PANTHER. First, the sequences used to create evolutionary trees are carefully selected to provide coverage of phylogenetic as well as functional information. Second, PANTHER is now a member of the InterPro Consortium, and the PANTHER hidden markov Models (HMMs) are distributed as part of InterProScan. Third, we have dramatically expanded the number of pathways associated with subfamilies in PANTHER. Pathways provide a detailed, structured representation of protein function in the context of biological reaction networks. PANTHER pathways were generated using the emergin

SUBMITTER: Mi H 

PROVIDER: S-EPMC1716723 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature