Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22.

ABSTRACT: Human DNA sequence variation data are useful for studying the origin, evolution, and demographic history of modern humans and the mechanisms of maintenance of genetic variability in human populations, and for detecting linkage association of disease. Here, we report worldwide variation data from a approximately 10-kilobase noncoding autosomal region. We identified 75 variant sites in 64 humans (128 sequences) and 463 variant sites among the human, chimpanzee, and orangutan sequences. Statistical tests suggested that the region is selectively neutral. The average nucleotide diversity (pi) across the region was 0.088% among all of the human sequences obtained, 0.085% among African sequences, and 0.082% among non-African sequences, supporting the view of a low nucleotide diversity ( approxima

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC17204 | biostudies-literature | 2000 Oct

REPOSITORIES: biostudies-literature