Relation between clinical presentation, Helicobacter pylori density, interleukin 1beta and 8 production, and cagA status.

ABSTRACT:

Background

It is not known whether cagA+ Helicobacter pylori in duodenal ulcer (DU) have enhanced virulence compared with non-DU cagA+ H pylori.

Aims

To investigate the relation between presentation, H pylori density, interleukin 1beta (IL-1beta) and IL-8 production, and cagA status.

Methods

Fifty DU and 50 gastritis patients with cagA+ H pylori and 11 with cagA- infections were studied. Bacterial density and cytokine production were assessed using the same biopsies. Cytokine production was also measured from supernatants of medium following coculture of H pylori with MKN-45 cells.

Results

There was no relation between H pylori density and cagA status. There was a dose dependent relation between mucosal cytokine levels and density of cagA+ H pylori. H pylori de

SUBMITTER: Yamaoka Y 

PROVIDER: S-EPMC1727763 | biostudies-literature | 1999 Dec

REPOSITORIES: biostudies-literature