Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease.

ABSTRACT:

Background and aims

Genetic predisposition for inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic linkage studies. Genetic linkage of IBD to chromosome 3 has been observed previously. A high density analysis of chromosome 3p was performed to confirm prior linkages and elucidate potential genetic associations.

Methods

Forty three microsatellite markers on chromosome 3 were genotyped in 353 affected sibling pairs of North European Caucasian extraction (average marker density 2 cM in the linkage interval). Marker order was defined by genetic and radiation hybrid techniques.

Results

The maximum single point logarithm of odds (LOD) score was observed for Crohn's disease at D3S3591. Peak multipoint LOD scores of 1.65 and 1.40 for the IBD p

SUBMITTER: Hampe J 

PROVIDER: S-EPMC1728207 | biostudies-literature | 2001 Feb

REPOSITORIES: biostudies-literature