Upregulation of Reg 1alpha and GW112 in the epithelium of inflamed colonic mucosa.

ABSTRACT:

Background and aims

Colonic epithelium is involved in the regulation of intestinal function and mucosal immune responses, and its function is altered in inflammatory bowel disease (IBD). However, a comprehensive analysis of the genetic alterations in inflamed colonic epithelium is not available at present. The aim of our study was to detect genes that are preferentially expressed in inflamed colonic epithelia and clarify the biochemical responses of epithelial cells in inflamed colonic mucosa.

Methods

cDNA representation difference analysis was used to identify candidate genes selectively expressed in inflamed colonic epithelia. Selective expression of these genes in the epithelium of inflamed colonic mucosa, including IBD and non-IBD tissues, was examined by real time polym

SUBMITTER: Shinozaki S 

PROVIDER: S-EPMC1728274 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature