Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects.

ABSTRACT:

Background and methods

Autism is a severe neurodevelopmental disorder, which has a complex genetic predisposition. The ratio of males to females affected by autism is approximately 4:1, suggesting that sex specific factors are involved in its development. We reported previously the results of a genomewide screen for autism susceptibility loci in 83 affected sibling pairs (ASP), and follow up analysis in 152 ASP. Here, we report analysis of an expanded sample of 219 ASP, using sex and parent of origin linkage modelling at loci on chromosomes 2, 7, 9, 15, and 16.

Results

The results suggest that linkage to chromosomes 7q and 16p is contributed largely by the male-male ASP (MLS = 2.55 v 0.12, and MLS = 2.48 v 0.00, for the 145 male-male and 74 male-female/female-female ASP on c

SUBMITTER: Lamb JA 

PROVIDER: S-EPMC1735992 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature