Association of a COL1A1 polymorphism with lumbar disc disease in young military recruits.

ABSTRACT:

Background

Lumbar disc disease (LDD), one of the most common conditions for which patients seek medical care, has been associated with sequence changes of the COL genes. COL1A1, however, has not been studied in young patients with LDD; COL1A1 polymorphisms have been associated with bone mineral density (BMD) in several populations and with LDD in older adults.

Objective

To study COL1A1 polymorphisms in young Greek army recruits with LDD.

Subjects

These young soldiers were diagnosed with early LDD at the time of their presentation to a military training site. All patients had radiological confirmation of their disease; a control group was also studied.

Methods

Sp1-binding site polymorphism of the COL1A1 gene was investigated by standard methods.

Results

T

SUBMITTER: Tilkeridis C 

PROVIDER: S-EPMC1736100 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature