Association of genes of lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study.

ABSTRACT:

Background

Dyslipidaemia is a well known risk factor for cardiovascular disease (CVD). Lipid metabolism is affected by a range of genes and proteins. This study investigated whether some of these genes are associated with measures of subclinical CVD.

Methods

Polymorphisms of paraoxonase 1 and 2, cholesteryl ester transfer protein, hepatic lipase, and lipoprotein lipase were tested for associations with measures of subclinical CVD including carotid intima-media thickness measured by B-mode ultrasound and carotid and coronary arterial calcification measured by computed tomography. Analysis was performed in 620 European American participants in the Diabetes Heart Study, 83% of whom had type 2 diabetes mellitus. Associations of genotypes with subclinical CVD were tested by compu

SUBMITTER: Burdon KP 

PROVIDER: S-EPMC1736137 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature