Air samples versus biomarkers for epidemiology.

ABSTRACT:

Background

It has been speculated on theoretical grounds that biomarkers are superior surrogates for chemical exposures to air samples in epidemiology studies.

Methods and results

Biomarkers were classified according to their position in the exposure-disease continuum-that is, parent compound, reactive intermediate, stable metabolite, macromolecular adduct, or measure of cellular damage. Because airborne exposures and these different biomarkers are time series that vary within and between persons in a population, they are all prone to measurement error effects when used as surrogates for true chemical exposures. It was shown that the attenuation bias in the estimated slope characterising a log exposure-log disease relation should decrease as the within- to between-person var

SUBMITTER: Lin YS 

PROVIDER: S-EPMC1740917 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature