Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis.

ABSTRACT: BACKGROUND:Recent studies of the role of bacteria in chronic bronchitis have shown that bacterial colonisation is associated with enhanced inflammation and that purulent acute exacerbations of chronic bronchitis (AECB) are associated with bacteria and characterised by increased inflammation. Changes in bronchial inflammation in response to the success or failure of bacterial eradication following AECB were therefore studied. METHODS:Bacterial quantitative culture and sputum markers of inflammation (myeloperoxidase (MPO), neutrophil elastase, leukotriene B4 (LTB4), sol:serum albumin ratio, and secretory leukoprotease inhibitor) were measured in patients presenting with culture positive purulent AECB and repeated 10 days and 2 months later. 41 patients provided sputum sufficient for both bac

SUBMITTER: White AJ 

PROVIDER: S-EPMC1746781 | biostudies-literature | 2003 Aug

REPOSITORIES: biostudies-literature