Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status.

ABSTRACT:

Background

Skeletal muscle weakness is assumed to be present in patients with sarcoidosis but has never been reported in a consecutive group of patients. Moreover, its relationship with previously observed exercise intolerance and reduced health status has never been studied in these patients.

Methods

Pulmonary function, skeletal and respiratory muscle forces, peak and functional exercise capacity, health status, and the circulating levels of inflammatory and anabolic markers were determined in 25 patients with sarcoidosis who complained of fatigue (15 men) and in 21 healthy subjects (13 men).

Results

Patients with sarcoidosis had lower respiratory and skeletal muscle forces, reduced exercise capacity and health status, higher anxiety and depression scores, and higher

SUBMITTER: Spruit MA 

PROVIDER: S-EPMC1747159 | biostudies-literature | 2005 Jan

REPOSITORIES: biostudies-literature