Hypoxaemia enhances peripheral muscle oxidative stress in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Because oxidative stress affects muscle function, the underlying mechanism to explain exercise induced peripheral muscle oxidative stress in patients with chronic obstructive pulmonary disease (COPD) is clinically relevant. This study investigated whether chronic hypoxaemia in COPD worsens peripheral muscle oxidative stress and whether an abnormal muscle inflammatory process is associated with it.

Methods

Nine chronically hypoxaemic and nine non-hypoxaemic patients performed repeated knee extensions until exhaustion. Biopsy specimens were taken from the vastus lateralis muscle before and 48 hours after exercise. Muscle oxidative stress was evaluated by lipid peroxidation (lipofuscin and thiobarbituric acid reactive substances (TBARs)) and oxidised proteins. Inflam

SUBMITTER: Koechlin C 

PROVIDER: S-EPMC1747208 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature