Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke.

ABSTRACT: OBJECTIVE:To provide a hazard prioritisation for reported chemical constituents of cigarette smoke using toxicological risk assessment principles and assumptions. The purpose is to inform prevention efforts using harm reduction. DATA SOURCES:International Agency for Research on Cancer Monographs; California and US Environmental Protection Agency cancer potency factors (CPFs) and reference exposure levels; scientific journals and government reports from the USA, Canada, and New Zealand. STUDY SELECTION:This was an inclusive review of studies reporting yields of cigarette smoke constituents using standard ISO methods. DATA EXTRACTION:Where possible, the midpoint of reported ranges of yields was used. DATA SYNTHESIS:Data on 158 compounds in cigarette smoke were found. Of these, 45 were known

SUBMITTER: Fowles J 

PROVIDER: S-EPMC1747794 | biostudies-literature | 2003 Dec

REPOSITORIES: biostudies-literature