Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding--a European perspective.

ABSTRACT:

Introduction

Our aim was to develop consensus guidelines for use of recombinant activated factor VII (rFVIIa) in massive hemorrhage.

Methods

A guidelines committee derived the recommendations using clinical trial and case series data identified through searches of available databases. Guidelines were graded on a scale of A-E according to the strength of evidence available. Consensus was sought among the committee for each recommendation.

Results

A recommendation for use of rFVIIa in blunt trauma was made (grade B). rFVIIa might also be beneficial in post-partum hemorrhage (grade E), uncontrolled bleeding in surgical patients (grade E) and bleeding following cardiac surgery (grade D). rFVIIa could not be recommended for use: in penetrating trauma (grade B); prophylacti

SUBMITTER: Vincent JL 

PROVIDER: S-EPMC1750973 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature