The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.

ABSTRACT: Notch signaling, which is crucial to metazoan development, requires endocytosis of Notch ligands, such as Delta and Serrate. Neuralized is a plasma membrane-associated ubiquitin ligase that is required for neural development and Delta internalization. Neuralized is comprised of three domains that include a C-terminal RING domain and two neuralized homology repeat (NHR) domains. All three domains are conserved between organisms, suggesting that these regions of Neuralized are functionally important. Although the Neuralized RING domain has been shown to be required for Delta ubiquitination, the function of the NHR domains remains elusive. Here we show that neuralized, a well-characterized neurogenic allele, exhibits a mutation in a conserved residue of the NHR1 domain that results in misloca

SUBMITTER: Commisso C 

PROVIDER: S-EPMC1751308 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature