Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD).

ABSTRACT: Amyloidogenic processing of the amyloid precursor protein (APP) results in the generation of beta-amyloid, the main constituent of Alzheimer plaques, and the APP intracellular domain (AICD). Recently, it has been demonstrated that AICD has transactivation potential; however, the targets of AICD-dependent gene regulation and hence the physiological role of AICD remain largely unknown. We analyzed transcriptome changes during AICD-dependent gene regulation by using a human neural cell culture system inducible for expression of AICD, its coactivator FE65, or the combination of both. Induction of AICD was associated with increased expression of genes with known function in the organization and dynamics of the actin cytoskeleton, including alpha2-Actin and Transgelin (SM22). AICD target genes w

SUBMITTER: Muller T 

PROVIDER: S-EPMC1751311 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature