Ontology highlight
ABSTRACT:
SUBMITTER: Gupta R
PROVIDER: S-EPMC1751539 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Gupta Rigu R Sharma Sudha S Doherty Kevin M KM Sommers Joshua A JA Cantor Sharon B SB Brosh Robert M RM
Nucleic acids research 20061201 22
The BRCA1 associated C-terminal helicase (BACH1) associated with breast cancer has been implicated in double strand break (DSB) repair. More recently, BACH1 (FANCJ) has been genetically linked to the chromosomal instability disorder Fanconi Anemia (FA). Understanding the roles of BACH1 in cellular DNA metabolism and how BACH1 dysfunction leads to tumorigenesis requires a comprehensive investigation of its catalytic mechanism and molecular functions in DNA repair. In this study, we have determine ...[more]