IGNM: a database of protein functional motions based on Gaussian Network Model.

ABSTRACT:

Motivation

The knowledge of protein structure is not sufficient for understanding and controlling its function. Function is a dynamic property. Although protein structural information has been rapidly accumulating in databases, little effort has been invested to date toward systematically characterizing protein dynamics. The recent success of analytical methods based on elastic network models, and in particular the Gaussian Network Model (GNM), permits us to perform a high-throughput analysis of the collective dynamics of proteins.

Results

We computed the GNM dynamics for 20 058 structures from the Protein Data Bank, and generated information on the equilibrium dynamics at the level of individual residues. The results are stored on a web-based system called iGNM and configur

SUBMITTER: Yang LW 

PROVIDER: S-EPMC1752228 | biostudies-literature | 2005 Jul

REPOSITORIES: biostudies-literature