Thrombotic microangiopathic haemolytic anaemia and antiphospholipid antibodies.

ABSTRACT:

Objective

To analyse the clinical and laboratory features of patients with thrombotic microangiopathic haemolytic anaemia (TMHA) associated with antiphospholipid antibodies (aPL).

Methods

A computer assisted (PubMed) search of the literature was performed to identify all cases of TMHA associated with aPL from 1983 to December 2002.

Results

46 patients (36 female) with a mean (SD) age at presentation of TMHA of 34 (15) years were reviewed. Twenty eight (61%) patients had primary antiphospholipid syndrome (APS). TMHA was the first clinical manifestation of APS in 26 (57%) patients. The clinical presentations were haemolytic-uraemic syndrome (26%), catastrophic APS (23%), acute renal failure (15%), malignant hypertension (13%), thrombotic thrombocytopenic purpura (13%),

SUBMITTER: Espinosa G 

PROVIDER: S-EPMC1755024 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature