Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity.

ABSTRACT:

Objective

To determine the presence of raised titres of anti-serum amyloid P component (SAP) antibodies in patients with systemic lupus erythematosus (SLE) and to evaluate their correlation with clinical disease by the SLEDAI and clinical manifestations.

Methods

452 samples were screened for raised anti-SAP antibody titres by an ELISA. Clinical measures and SLEDAI scores were independently reviewed from medical records. 21 serial samples from 7 patients with SLE were assessed for a change in anti-SAP antibody titres after treatment.

Results

Raised anti-SAP antibody titres were detected in 145/328 (44%) SLE samples. In 112 randomly selected samples, 69/112 (62%) patients had raised anti-SAP antibodies and anti-dsDNA antibody titres, whereas only 32/112 (28%) had raised

SUBMITTER: Zandman-Goddard G 

PROVIDER: S-EPMC1755319 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature