A high-resolution map of segmental DNA copy number variation in the mouse genome.

ABSTRACT: Submicroscopic (less than 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. In some cases, CNVs that cause gene dosage effects have been implicated in phenotypic variation. CNVs have been detected in diverse species, including mice and humans. Published studies in mice have been limited by resolution and strain selection. We chose to study 21 well-characterized inbred mouse strains that are the focus of an international effort to measure, catalog, and disseminate phenotype data. We performed comparative genomic hybridization using long oligomer arrays to characterize CNVs in these strains. This technique increased the resolution of CNV detecti

SUBMITTER: Graubert TA 

PROVIDER: S-EPMC1761046 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature