Ontology highlight
ABSTRACT:
SUBMITTER: Noble CG
PROVIDER: S-EPMC1761425 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Noble Christian G CG Beuth Barbara B Taylor Ian A IA
Nucleic acids research 20061206 1
Pcf11 and Clp1 are subunits of cleavage factor IA (CFIA), an essential polyadenylation factor in Saccahromyces cerevisiae. We have determined the structure of a ternary complex of Clp1 together with ATP and the Clp1-binding region of Pcf11. Clp1 contains three domains, a small N-terminal beta sandwich domain, a C-terminal domain containing a novel alpha/beta-fold and a central domain that binds ATP. The arrangement of the nucleotide binding site is similar to that observed in SIMIBI-class ATPase ...[more]