TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

ABSTRACT:

Background

Common polymorphisms of the transcription factor 7-like 2 gene (TCF7L2) have recently been associated with type 2 diabetes. We examined whether the two most strongly associated variants (rs12255372 and rs7903146) predict the progression to diabetes in persons with impaired glucose tolerance who were enrolled in the Diabetes Prevention Program, in which lifestyle intervention or treatment with metformin was compared with placebo.

Methods

We genotyped these variants in 3548 participants and performed Cox regression analysis using genotype, intervention, and their interactions as predictors. We assessed the effect of genotype on measures of insulin secretion and insulin sensitivity at baseline and at one year.

Results

Over an average period of three years, par

SUBMITTER: Florez JC 

PROVIDER: S-EPMC1762036 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature