Cross species association examination of UCN3 and CRHR2 as potential pharmacological targets for antiobesity drugs.

ABSTRACT:

Background

Obesity now constitutes a leading global public health problem. Studies have shown that insulin resistance affiliated with obesity is associated with intramyocellular lipid (IMCL) accumulation. Therefore, identification of genes associated with the phenotype would provide a clear target for pharmaceutical intervention and care for the condition. We hypothesized that urocortin 3 (UCN3) and corticotropin-releasing hormone receptor 2 (CRHR2) are associated with IMCL and subcutaneous fat depth (SFD), because the corticotropin-releasing hormone family of peptides are capable of strong anorectic and thermogenic effects.

Methodology/principal findings

We annotated both bovine UCN3 and CRHR2 genes and identified 12 genetic mutations in the former gene and 5 genetic marker

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC1762311 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature