A mouse stromal response to tumor invasion predicts prostate and breast cancer patient survival.

ABSTRACT: Primary and metastatic tumor growth induces host tissue responses that are believed to support tumor progression. Understanding the molecular changes within the tumor microenvironment during tumor progression may therefore be relevant not only for discovering potential therapeutic targets, but also for identifying putative molecular signatures that may improve tumor classification and predict clinical outcome. To selectively address stromal gene expression changes during cancer progression, we performed cDNA microarray analysis of laser-microdissected stromal cells derived from prostate intraepithelial neoplasia (PIN) and invasive cancer in a multistage model of prostate carcinogenesis. Human orthologs of genes identified in the stromal reaction to tumor progression in this mouse model wer

SUBMITTER: Bacac M 

PROVIDER: S-EPMC1762322 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature