Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality.

ABSTRACT:

Background

Recently, a -168A-->G polymorphism in the MHC class II transactivator gene (MHC2TA) was shown to be associated with increased susceptibility to myocardial infarction (MI).

Aim

To confirm the association between the MHC2TA -168A-->G polymorphism and MI and to study its putative role for microalbuminuria, the metabolic syndrome (MetS) and cardiovascular mortality.

Materials and methods

Using an allelic discrimination method we genotyped 11,064 individuals from three study populations: 1) 4,432 individuals from the Botnia type 2 diabetes (T2D) study, 2) 1,222 patients with MI and 2,345 control subjects participating in the Malmö Diet and Cancer study and comprising an MI case-control sample, and 3) 3,065 T2D patients from the Local Swedish Diabetes registry.

SUBMITTER: Lindholm E 

PROVIDER: S-EPMC1762368 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature