Soluble TNF mediates the transition from pulmonary inflammation to fibrosis.

ABSTRACT:

Background

Fibrosis, the replacement of functional tissue with excessive fibrous tissue, can occur in all the main tissues and organ systems, resulting in various pathological disorders. Idiopathic Pulmonary Fibrosis is a prototype fibrotic disease involving abnormal wound healing in response to multiple sites of ongoing alveolar epithelial injury.

Methodology/principal findings

To decipher the role of TNF and TNF-mediated inflammation in the development of fibrosis, we have utilized the bleomycin-induced animal model of Pulmonary Fibrosis and a series of genetically modified mice lacking components of TNF signaling. Transmembrane TNF expression is shown to be sufficient to elicit an inflammatory response, but inadequate for the transition to the fibrotic phase of the diseas

SUBMITTER: Oikonomou N 

PROVIDER: S-EPMC1762410 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature