Biogenesis and dynamics of mitochondria during the cell cycle: significance of 3'UTRs.

ABSTRACT: Nowadays, we are facing a renaissance of mitochondria in cancer biology. However, our knowledge of the basic cell biology and on the timing and mechanisms that control the biosynthesis of mitochondrial constituents during progression through the cell cycle of mammalian cells remain largely unknown. Herein, we document the in vivo changes on mitochondrial morphology and dynamics that accompany cellular mitosis, and illustrate the following key points of the biogenesis of mitochondria during progression of liver cells through the cycle: (i) the replication of nuclear and mitochondrial genomes is synchronized during cellular proliferation, (ii) the accretion of OXPHOS proteins is asynchronously regulated during proliferation being the synthesis of beta-F1-ATPase and Hsp60 carried out also at

SUBMITTER: Martinez-Diez M 

PROVIDER: S-EPMC1762426 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature