Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes.

ABSTRACT:

Background

Mammalian antimicrobial peptides (AMPs) are effectors of the innate immune response. A multitude of signals coming from pathways of mammalian pathogen/pattern recognition receptors and other proteins affect the expression of AMP-coding genes (AMPcgs). For many AMPcgs the promoter elements and transcription factors that control their tissue cell-specific expression have yet to be fully identified and characterized.

Results

Based upon the RIKEN full-length cDNA and public sequence data derived from human, mouse and rat, we identified 178 candidate AMP transcripts derived from 61 genes belonging to 29 AMP families. However, only for 31 mouse genes belonging to 22 AMP families we were able to determine true orthologous relationships with 30 human and 15 rat sequences.

SUBMITTER: Brahmachary M 

PROVIDER: S-EPMC1764486 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature