Evolutionary history of LINE-1 in the major clades of placental mammals.

ABSTRACT:

Background

LINE-1 constitutes an important component of mammalian genomes. It has a dynamic evolutionary history characterized by the rise, fall and replacement of subfamilies. Most data concerning LINE-1 biology and evolution are derived from the human and mouse genomes and are often assumed to hold for all placentals.

Methodology

To examine LINE-1 relationships, sequences from the 3' region of the reverse transcriptase from 21 species (representing 13 orders across Afrotheria, Xenarthra, Supraprimates and Laurasiatheria) were obtained from whole genome sequence assemblies, or by PCR with degenerate primers. These sequences were aligned and analysed.

Principal findings

Our analysis reflects accepted placental relationships suggesting mostly lineage-specific LINE-1 fa

SUBMITTER: Waters PD 

PROVIDER: S-EPMC1764860 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature