The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum.

ABSTRACT: Plasmodium falciparum is the causative agent of the most burdensome form of human malaria, affecting 200-300 million individuals per year worldwide. The recently sequenced genome of P. falciparum revealed over 5,400 genes, of which 60% encode proteins of unknown function. Insights into the biochemical function and regulation of these genes will provide the foundation for future drug and vaccine development efforts toward eradication of this disease. By analyzing the complete asexual intraerythrocytic developmental cycle (IDC) transcriptome of the HB3 strain of P. falciparum, we demonstrate that at least 60% of the genome is transcriptionally active during this stage. Our data demonstrate that this parasite has evolved an extremely specialized mode of transcriptional regulation that produce

SUBMITTER: Bozdech Z 

PROVIDER: S-EPMC176545 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature