Meta-analysis of randomised controlled trials of the effectiveness of antiarrhythmic agents at promoting sinus rhythm in patients with atrial fibrillation.

ABSTRACT:

Objective

To conduct a meta-analysis of randomised controlled trials to estimate the effectiveness of antiarrhythmic drugs at promoting sinus rhythm in patients with atrial fibrillation.

Design

Articles were identified by using a comprehensive search of English language papers indexed in Medline from 1966 to August 2001. For the outcomes of sinus rhythm and death, a random effects model was used to model repeated assessments within a study at different time points.

Setting

Emergency departments and ambulatory clinics.

Patients

Patients with atrial fibrillation.

Interventions

Antiarrhythmic agents grouped according to their Vaughan-Williams class.

Main outcome measures

Sinus rhythm and mortality.

Results

91 articles met a priori criteria for

SUBMITTER: Nichol G 

PROVIDER: S-EPMC1767130 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature