Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of a total of 2,500 miRNAs in 13 cardiovascular disease patients and 5 healthy controls In the study presented here, a well-defined cohort of 13 cardiovascular disease cases and 5 healthy controls was used to acquire expression profiles of a total of 2,500 unique genes.
Project description:Frailty in elderly cardiovascular disease (CVD) patients is linked to declining functional capacity and procedural complications. This study investigated the transcriptomic signature of frailty in patients ≥70 years undergoing cardiac surgery or TAVI. Frailty was assessed using mobility, gait speed, and handgrip strength. Muscle samples were collected during surgery for RNA sequencing, and gene expression was analyzed. Transcriptomic analysis identified 10 frailty-associated genes, with S100A1 showing the strongest association. Functional studies confirmed S100A1’s role in muscle function, and higher blood S100A1 levels correlated with handgrip strength in a second cohort. S100A1 is a potential target for addressing frailty in elderly CVD patients and offers insights into genetic factors contributing to frailty.
Project description:Individualized outcome prediction classifiers were successfully constructed through expression profiling of a total of 2,500 miRNAs in 13 cardiovascular disease patients and 5 healthy controls