Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array.

ABSTRACT:

Background

Alternative splicing is a mechanism for increasing protein diversity by excluding or including exons during post-transcriptional processing. Alternatively spliced proteins are particularly relevant in oncology since they may contribute to the etiology of cancer, provide selective drug targets, or serve as a marker set for cancer diagnosis. While conventional identification of splice variants generally targets individual genes, we present here a new exon-centric array (GeneChip Human Exon 1.0 ST) that allows genome-wide identification of differential splice variation, and concurrently provides a flexible and inclusive analysis of gene expression.

Results

We analyzed 20 paired tumor-normal colon cancer samples using a microarray designed to detect over one million p

SUBMITTER: Gardina PJ 

PROVIDER: S-EPMC1769375 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature