Effects of the diabetes linked TCF7L2 polymorphism in a representative older population.

ABSTRACT:

Background

A polymorphism in the transcription factor 7-like 2 (TCF7L2) gene has been found to be associated with type 2 diabetes in case-control studies. We aimed to estimate associations of the marker rs7903146 (C/T) polymorphism with fasting glucose, lipids, diabetes prevalence and complications in an older general population.

Methods

In total, 944 subjects aged > or = 65 years from the population representative InCHIANTI study were enrolled in this study. Those with fasting blood glucose of > or = 7 mmol/l or physician diagnosis were considered diabetic. Cut-off points for impaired fasting glucose (IFG) were > or = 5.6 mmol/l to < 7 mmol/l.

Results

In the general population sample, minor (T) allele carriers of rs7903146 had higher fasting blood glucose (FBG) (p =

SUBMITTER: Melzer D 

PROVIDER: S-EPMC1769391 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature