Mast cells dysregulate apoptotic and cell cycle genes in mucosal squamous cell carcinoma.

ABSTRACT:

Background

Mucosal squamous cell carcinoma of the head and neck is a disease of high mortality and morbidity. Interactions between the squamous cell carcinoma and the host's local immunity, and how the latter contributes to the biological behavior of the tumor are unclear. In vivo studies have demonstrated sequential mast cell infiltration and degranulation during squamous cell carcinogenesis. The degree of mast cell activation correlates closely with distinct phases of hyperkeratosis, dysplasia, carcinoma in-situ and invasive carcinoma. However, the role of mast cells in carcinogenesis is unclear.

Aim

This study explores the effects of mast cells on the proliferation and gene expression profile of mucosal squamous cell carcinoma using human mast cell line (HMC-1) and human

SUBMITTER: Ch'ng S 

PROVIDER: S-EPMC1769399 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature