Gene expression profiles of giant hairy naevi.

ABSTRACT:

Background

Congenital neomelanocytic naevi appear in nearly 1% of newborns. Giant hairy naevi (GHN) are uncommon lesions covering large areas of the body. They are of concern because they have the potential to transform into malignant melanomas.

Aims

To describe gene expression profiles of GHN and nearby normal skin from patients with GHN and normal control skin (from patients with cleft lip/palate).

Methods

Tissues from three patients with GHN and two normal controls were studied for differences in gene expression profiles. Total RNA was isolated from normal skin near the hairy naevus, GHN, and skin from normal controls. The RNA samples were subjected to probe labelling, hybridisation to chips, and image acquisition according to the standard Affymetrix protocol.

R

SUBMITTER: Dasu MR 

PROVIDER: S-EPMC1770402 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature