Expression of CD1d in human scalp skin and hair follicles: hair cycle related alterations.

ABSTRACT:

Background

CD1d belongs to a family of antigen presenting molecules that are structurally and distantly related to the classic major histocompatibility complex class I (MHC I) proteins. However, unlike MHC I molecules, which bind protein antigens, CD1d binds to lipid and glycolipid antigens. CD1d is expressed by cells of lymphoid and myeloid origin, and by cells outside of the lymphoid and myeloid lineages, such as human keratinocytes of psoriatic skin.

Aims

To investigate whether CD1d is also expressed in sun exposed skin and in the immuno-privileged anagen hair follicle.

Materials/methods

CD1d immunoreactivity was studied in human scalp skin and hair follicles of healthy women in situ by immunofluorescent and light microscopic immunohistology. Skin biopsies were obt

SUBMITTER: Adly MA 

PROVIDER: S-EPMC1770800 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature