Gene expression in peripheral blood mononuclear cells from patients with chronic fatigue syndrome.

ABSTRACT:

Background

Chronic fatigue syndrome (CFS) is a multisystem disease, the pathogenesis of which remains undetermined.

Aims

To test the hypothesis that there are reproducible abnormalities of gene expression in patients with CFS compared with normal healthy persons.

Methods

To gain further insight into the pathogenesis of this disease, gene expression was analysed in peripheral blood mononuclear cells from 25 patients with CFS diagnosed according to the Centers for Disease Control criteria and 25 normal blood donors matched for age, sex, and geographical location, using a single colour microarray representing 9522 human genes. After normalisation, average difference values for each gene were compared between test and control groups using a cutoff fold difference of expre

SUBMITTER: Kaushik N 

PROVIDER: S-EPMC1770875 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature