Microsatellite instability and gastric non-invasive neoplasia in a high risk population in Cesena, Italy.

ABSTRACT:

Background/aims

In the natural history of gastric cancer, non-invasive neoplasia (NiN) precedes invasive carcinoma. A histological classification of gastric NiN has recently been proposed by a World Health Organisation international panel of experts. Genetic instability is known to be among the molecular pathways involved in gastric oncogenesis. In this retrospective cross sectional study, microsatellite instability (MSI) was analysed in a consecutive series of NiN and NiN related histological alterations from a northern Italian region at high risk for gastric cancer.

Patients/methods

Fifty five consecutive cases (indefinite for NiN, 29 cases; low grade NiN, 17 cases; high grade NiN, nine cases) were analysed by radioactive polymerase chain reaction and electrophoresis for m

SUBMITTER: Rugge M 

PROVIDER: S-EPMC1770888 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature