Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays.

ABSTRACT:

Background

Skin cancer accounts for 1/3 of all newly diagnosed cancer. Although seldom fatal, basal cell carcinoma (BCC) is associated with severe disfigurement and morbidity. BCC has a unique interest for researchers, as although it is often locally invasive, it rarely metastasises. This paper, reporting the first whole genome expression microarray analysis of skin cancer, aimed to investigate the molecular profile of BCC in comparison to non-cancerous skin biopsies. RNA from BCC and normal skin specimens was analysed using Affymetrix whole genome microarrays. A Welch t-test was applied to data normalised using dCHIP to identify significant differentially-expressed genes between BCC and normal specimens. Principal component analysis and support vector machine analysis were perform

SUBMITTER: O'Driscoll L 

PROVIDER: S-EPMC1770933 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature