Gene expression profiles of primary colorectal carcinomas, liver metastases, and carcinomatoses.

ABSTRACT:

Background

Despite the fact that metastases are the leading cause of colorectal cancer deaths, little is known about the underlying molecular changes in these advanced disease stages. Few have studied the overall gene expression levels in metastases from colorectal carcinomas, and so far, none has investigated the peritoneal carcinomatoses by use of DNA microarrays. Therefore, the aim of the present study is to investigate and compare the gene expression patterns of primary carcinomas (n = 18), liver metastases (n = 4), and carcinomatoses (n = 4), relative to normal samples from the large bowel.

Results

Transcriptome profiles of colorectal cancer metastases independent of tumor site, as well as separate profiles associated with primary carcinomas, liver metastases, or perito

SUBMITTER: Kleivi K 

PROVIDER: S-EPMC1770935 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature