Distinct methylated profiles in Helicobacter pylori dependent and independent gastric MALT lymphomas.

ABSTRACT: BACKGROUND:Gastric mucosa associated lymphoid tissue (MALT) lymphomas are clinically subdivided into Helicobacter pylori dependent and independent, according to H. pylori infection and the therapeutic course. In previous reports it has been suggested that H. pylori independent cases develop from H. pylori dependent cases, and sometimes transform into high grade diffuse large B cell lymphomas (DLBCLs). METHODS:To better understand the pathogenesis of H. pylori dependent and independent MALT lymphomas, we analysed the methylation profiles of eight independent CpG islands, including p15, p16, p73, hMLH1, death associated protein kinase, MINT1, MINT2, and MINT31 in H. pylori dependent and independent MALT lymphomas, DLBCLs, and H. pylori associated chronic gastritis. RESULTS:We first confirmed

SUBMITTER: Kaneko Y 

PROVIDER: S-EPMC1773639 | biostudies-literature | 2003 May

REPOSITORIES: biostudies-literature